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Article

Molecular dynamics simulations reveal structural instability of human trypsin inhibitor upon D50E and Y54H mutations.

Journal of molecular modeling - 1 Feb 2013

Mokmak Wanwimon, Chunsrivirot Surasak, Assawamakin Anunchai, Choowongkomon Kiattawee, Tongsima Sissades

Abstract excerpt

Serine protease inhibitor Kazal type 1 (SPINK1) plays an important role in protecting the pancreas against premature trypsinogen activation that causes pancreatitis. Various mutations in the SPINK1 gene were shown to be associated with patients with pancreatitis. Recent transfection studies identified intracellular folding defects, probably caused by mutation induced misfolding of D50E and Y54H mutations, as a...

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Source

Identifiers

PMID: 22955423
DOI: 10.1007/s00894-012-1565-2

Genes

SPINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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