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Article

Secreted factors derived from obese visceral adipose tissue regulate the expression of breast malignant transformation genes.

International journal of obesity (2005) - 1 Mar 2016

Crujeiras A B, Cabia B, Carreira M C, Amil M, Cueva J, Andrade S, Seoane L M, Pardo M, Sueiro A, Baltar J, Morais T, Monteiro M P, Lopez-Lopez R, Casanueva F F

Abstract excerpt

BACKGROUND/OBJECTIVES: Obese adipose tissue, especially the visceral depot, exhibits altered production of several molecules that could have a role on the initiation/promotion of breast cancer development. The aim of this work was to evaluate the effect of excess adipose tissue and its secreted factors on the expression of genes involved in the early steps of tumor promotion on the mammary gland. SUBJECTS AND...

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Source

Identifiers

PMID: 26443342
DOI: 10.1038/ijo.2015.208

Genes

GSTM2
MYC
PTEN
SIRT1
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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