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Dual-mode ClfA-targeting DARPin biologics protect against diverse methicillin-resistant <i>Staphylococcus aureus</i> strains

2026-01-09

Abstract excerpt

Staphylococcus aureus uses the adhesin clumping factor A (ClfA) to bind fibrinogen and promote invasive infection through two distinct interfaces: an exposed, low-affinity site on the N3 head domain and a buried, high-affinity “dock, lock, and latch” (DLL) trench that is exposed only under shear. This dual-interface architecture allows limited antibody penetration, as antibodies typically block only the exposed si...

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Literature Corpus work
938a6b67-d1a1-53eb-ab0b-d3094b3b3e87
DOI
10.64898/2026.01.09.698026
Open publication

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Dual-mode ClfA-targeting DARPin biologics protect against diverse methicillin-resistant <i>Staphylococcus aureus</i> strainsDOI 10.64898/2026.01.09.698026
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