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Article

Weaker N-Terminal Interactions for the Protective over the Causative Aβ Peptide Dimer Mutants.

ACS chemical neuroscience - 20 Jun 2018

Sharma Bhanushee, Ranganathan Srivathsan V, Belfort Georges

Abstract excerpt

Knowing that abeta amyloid peptide (Aβ42) dimers are the smallest and most abundant neurotoxic oligomers for Alzheimer's disease (AD), we used molecular simulations with advanced sampling methods (replica-exchange) to characterize and compare interactions between the N-termini (residues 1-16) of wild type (WT-WT) and five mutant dimers under constrained and unconstrained conditions. The number of contacts and...

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PMID: 29465978
DOI: 10.1021/acschemneuro.7b00412

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