Article

Sleep as a window into thalamocortical pathology: generative modeling implicates NMDA receptor hypofunction in 22q11.2 deletion syndrome

2025-08-05

Abstract excerpt

<h4>Background</h4> 22q11.2 deletion syndrome (22q11.2DS) is a strong genetic risk factor for neuropsychiatric conditions, including autism, ADHD, intellectual disability, and schizophrenia. Up to 25% of adults with 22q11.2DS get diagnosed with schizophrenia and 40% develop psychotic conditions more broadly. Sleep disturbances and altered sleep EEG in 22q11.2DS suggest underlying thalamocortical dysfunction. Howe...

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Literature Corpus work: aa243287-e328-52e2-8bc1-7e90f598469d
DOI: 10.1101/2025.08.01.25332824

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