Article

A hippocampal neuroimaging signature of neurovascular insulin signalling links metabolism to mood

2026-06-18

Abstract excerpt

Depression is a leading cause of global disability and is increasingly linked to systemic metabolic dysfunctions, including insulin resistance. However, the biological pathways connecting metabolic state to affective symptoms are unresolved. A growing body of evidence indicates that insulin, beyond its role in systemic glucose homeostasis, supports brain metabolism, synaptic function and cognition, yet its contrib...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa1ec077-6d38-5e3b-9e4a-f2efa19ab197
DOI: 10.64898/2026.06.17.732833

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A hippocampal neuroimaging signature of neurovascular insulin signalling links metabolism to moodDOI 10.64898/2026.06.17.732833Read

Associations Between Metabolic Syndrome, Depression, Plasma proteomics, and Neuroimaging Among Adults in the UK BiobankSemantic proximity Read

Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer's knock-in mouse phenotypes.Semantic proximity Read

Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistanceSemantic proximity Read

Depression and cognition are associated with lipid dysregulation in both a multigenerational study of depression and the National Health and Nutrition Examination Survey.Semantic proximity Read

Metabolic Psychiatry: A Conceptual Framework Targeting Metabolic Dysfunction in Psychiatric DiseaseSemantic proximity Read

Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s DiseaseSemantic proximity Read

Adipose tissue coregulates cognitive functionSemantic proximity Read

Insulin Resistance and Metabolic Comorbidities in Alzheimer’s DiseaseSemantic proximity Read

Associations of adiposity, atherogenic lipid phenotypes, systemic immune-inflammatory indices, and vascular aging markers with depression in US adults: NHANES 2005-2020.Semantic proximity Read

Chronic Unpredictable Stress Drives Non-pathological, Adaptive Metabolic Hormone Reprogramming with Reduced Insulin Resistance Linked to Depressive-like BehaviorsSemantic proximity Read

Differential associations of somatic and cognitive-affective symptoms of depression with inflammation and insulin resistance: cross-sectional and longitudinal results from the Emotional Distress Sub-Study of the GRADE studySemantic proximity Read

A <i>Gpr35</i> tuned gut-brain metabolic axis regulates depressive-like behaviorSemantic proximity Read