Article

A <i>Gpr35</i> tuned gut-brain metabolic axis regulates depressive-like behavior

2023-06-11

Abstract excerpt

Gene-environment interactions shape animal behavior and the susceptibility to neurobehavioral symptoms such as depression. However, little is known about the signaling pathway that integrates genetic and environmental inputs with neurobehavioral outcomes, preventing the development of targeted therapies. Here we report that Gpr35 engages a gut microbe-to-brain metabolic pathway to modulate neuronal plasticity and...

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Literature Corpus work: 2baac90f-0be7-55a7-b001-59c4d8f677bd
DOI: 10.1101/2023.06.11.542602

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