Article
Next-Generation HLA Sequence Analysis Uncovers Shared Risk Alleles Between Clinically Distinct Forms of Childhood Uveitis.
Investigative ophthalmology & visual science - 1 Jul 2021
Wennink Roos A W, de Boer Joke H, Hiddingh Sanne, Haasnoot Anne-Mieke J W, Kalinina Ayuso Viera, de Hoop Talitha, van Setten Jessica, Spierings Eric, Kuiper Jonas J W
Abstract excerpt
Purpose: Classical alleles of the human leukocyte antigen (HLA) complex have been linked to specific entities of pediatric noninfectious uveitis, yet genetic predisposition encoded by the HLA super-locus across the patient population remains understudied. Methods: We performed next-generation full-length sequencing of HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQB1, and HLA-DRB1 in 280 cases. Dense genotype data from 499...
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