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Article

Assessment of T-cell receptor repertoire and clonal expansion in peripheral T-cell lymphoma using RNA-seq data.

Scientific reports - 12 Sept 2017

Gong Qiang, Wang Chao, Zhang Weiwei, Iqbal Javeed, Hu Yang, Greiner Timothy C, Cornish Adam, Kim Jo-Heon, Rabadan Raul, Abate Francesco, Wang Xin, Inghirami Giorgio G, McKeithan Timothy W, Chan Wing C

Abstract excerpt

T-cell clonality of peripheral T-cell lymphoma (PTCL) is routinely evaluated with a PCR-based method using genomic DNA. However, there are limitations with this approach. The purpose of this study was to determine the utility of RNA-seq for assessing T-cell clonality and T-cell antigen receptor (TCR) repertoire of the neoplastic T-cells in 108 PTCL samples. TCR transcripts, including complementarity-determining...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to High-Throughput Nucleotide Sequencing

Share to Lymphoma, T-Cell, Peripheral

Share to Receptors, Antigen, T-Cell

Share to Sequence Analysis, RNA

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Source

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Identifiers

PMID: 28900149
DOI: 10.1038/s41598-017-11310-0
PMCID: PMC5595876

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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