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Article

Unraveling the role of PREX2 mutations as a biomarker for immunotherapy response in colorectal cancer.

Cancer biomarkers : section A of Disease markers - 1 Sept 2025

Peng Huan, Yang Pengmin, Wang Xintao, Zhao Xiaokai, Li Jieyi, Gong Ziying, Zhang Daoyun, Wang Zhiguo

Abstract excerpt

IntroductionImmunotherapy benefits gastrointestinal tumor patients. But traditional biomarkers like TMB and MSI can't precisely identify beneficiaries. Phosphatidylinositol - 3,4,5 - triphosphate - dependent Rac exchange factor 2 (PREX2) plays a complex role in tumorigenesis.MethodsIn a retrospective study of 1764 patients (1385 colorectal, 379 gastric), NGS of 639 genes and PD - L1 staining were done.ResultsIn...

Read the complete abstract on PubMed

Topics

Humans
Colorectal Neoplasms
Biomarkers, Tumor
Immunotherapy
Mutation
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Retrospective Studies

Guanine Nucleotide Exchange Factors

Middle Aged

Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 40971540
DOI: 10.1177/18758592251380454
PMCID: PMC13596779

Genes

PREX2
GC

Provenance

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