Article
Rosuvastatin and diosmetin inhibited the HSP70/TLR4 /NF-κB p65/NLRP3 signaling pathways and switched macrophage to M2 phenotype in a rat model of acute kidney injury induced by cisplatin.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Feb 2024
Saad Hebatallah M, Elekhnawy Engy, Shaldam Moataz A, Alqahtani Moneerah J, Altwaijry Najla, Attallah Nashwah G M, Hussein Ismail A, Ibrahim Hanaa A, Negm Walaa A, Salem Esraa A
Abstract excerpt
Numerous efforts to manage acute kidney injury (AKI) were unsuccessful because its pathophysiology is still poorly understood. Thus, our research hotspot was to explore the possible renoprotective effects of rosuvastatin (Ros) and diosmetin (D) on macrophage polarization and the role of HSP70/TLR4/MyD88/NF-κB p65/NLRP3/STAT3 signaling in cis-induced AKI and study the activity of D against uropathogenic bacteria....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.