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Article

Aberrant Bmp signaling and notochord delamination in the pathogenesis of esophageal atresia

26 Jan 2007

Abstract excerpt

Human foregut malformation known as esophageal atresia with tracheoesophageal fistula (EA/TEF) occurs in 1 in 4,000 live births with unknown etiology. We found that mice lacking Noggin (Nog(-/-)) displayed Type C EA/TEF, the most common form in humans, and notochordal defects strikingly similar to the adriamycin-induced rat EA/TEF model. In accord with esophageal atresia, Nog(-/-) embryos displayed reduction in...

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PMID: 17260385
DOI: 10.1002/dvdy.21075

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