Article
Primary cilia are critical for tracheoesophageal septation.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Mar 2024
Fitzsimons Lindsey Avery, Tasouri Evangelia, Willaredt Marc August, Stetson Daniel, Gojak Christian, Kirsch Joachim, Gardner Humphrey A R, Gorgas Karin, Tucker Kerry L
Abstract excerpt
INTRODUCTION: Primary cilia play pivotal roles in the patterning and morphogenesis of a wide variety of organs during mammalian development. Here we examined murine foregut septation in the cobblestone mutant, a hypomorphic allele of the gene encoding the intraflagellar transport protein IFT88, a protein essential for normal cilia function. RESULTS: We reveal a crucial role for primary cilia in foregut division,...
Topics
- Humans
- Animals
- Mice
- Hedgehog Proteins
- Cilia
- Alleles
- Ciliopathies
- Disease Models, Animal
- Mammals