Article
Disrupted endosomal trafficking of the Vangl-Celsr polarity complex underlies congenital anomalies in Xenopus trachea-esophageal morphogenesis.
Developmental cell - 22 Sept 2025
Edwards Nicole A, Rankin Scott A, Kashyap Adhish, Warren Alissa, Agricola Zachary N, Kenny Alan P, Kofron Matthew, Shen Yufeng, Chung Wendy K, Zorn Aaron M
Abstract excerpt
Disruptions in foregut morphogenesis can result in life-threatening conditions where the trachea and esophagus fail to separate, such as esophageal atresia (EA) and tracheoesophageal fistulas (TEFs). The developmental basis of these congenital anomalies is poorly understood, but recent genome sequencing reveals that de novo variants in intracellular trafficking genes are enriched in EA/TEF patients. Here, we...
Topics
- Animals
- Trachea
- Esophagus
- Endosomes
- Xenopus Proteins
- Cell Polarity
- Morphogenesis
- Xenopus laevis
- Esophageal Atresia
- rab GTP-Binding Proteins