Article

Comprehensive evaluation and interpretative insights of peptide-HLA binding prediction tools using explainable artificial intelligence

2025-04-16

Abstract excerpt

Accurate prediction of human leukocyte antigen class I (HLA-I) peptide binding is pivotal for immunological research, including vaccine development and immunotherapy. However, challenges such as tool performance variability, limited interpretability, and dataset quality hinder the broader applicability of existing models. Here, we conduct a comprehensive benchmarking of 17 prediction tools using a rigorously curat...

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Literature Corpus work: a9bc2255-5b91-5a49-be56-41c625ae7165
DOI: 10.1101/2025.04.10.648169

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