Article

Boldine prevents diabetes-induced skeletal muscle dysfunction by inhibiting large-pore channels

2026-02-26

Abstract excerpt

<h4>Background</h4> Diabetes mellitus leads to skeletal muscle dysfunction associated with loss of strength, impaired blood perfusion, lipid accumulation, and inflammation. The opening of large-pore channels has been linked to increased membrane permeability and inflammatory signaling in several pathologies. Boldine, an alkaloid from Peumus boldus , blocks large-pore channel activity and exhibits antioxidant and...

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Literature Corpus work: a9564b8a-997f-5748-8336-a13785d6ffa3
DOI: 10.64898/2026.02.24.707704

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