Article

Boldine prevents diabetes-induced skeletal muscle dysfunction by inhibiting large-pore channels

2026-04-09

Abstract excerpt

<title>Abstract</title> <p> Background Diabetes mellitus is associated with skeletal muscle dysfunction, including reduced strength, impaired perfusion, lipid accumulation, and inflammation. Activation of large-pore channels increases membrane permeability and inflammatory signaling. Boldine, an alkaloid from <italic>Peumus boldus</italic> , inhibits these channels and exhibits antioxidant and anti-inflammato...

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Literature Corpus work: 71ae3d8d-2efc-504b-bc56-ba0edd3e29f3
DOI: 10.21203/rs.3.rs-9284067/v1

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