Article

Integrated multiomic analysis identifies <i>TRIP13</i> as a mediator of alveolar epithelial type II cell dysfunction in idiopathic pulmonary fibrosis

2024-04-12

Abstract excerpt

<h4>SUMMARY</h4> Idiopathic pulmonary fibrosis (IPF) is a lethal progressive lung disease urgently needing new therapies. Current treatments only delay disease progression, leaving lung transplant as the sole remaining option. Recent studies support a model whereby IPF arises because alveolar epithelial type II (AT2) cells, which normally mediate distal lung regeneration, acquire airway and/or mesenchymal charact...

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Literature Corpus work: a94021d5-af13-5b1b-832e-59493af82e5c
DOI: 10.1101/2024.04.05.588292

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