Article

Temozolomide-induced glioma cytotoxicity is enhanced by inhibition of Sirt7, which is involved in growth and progression and is regulated by miR-148a-3p

2024-02-29

Abstract excerpt

<h4>Background: </h4> Glioma is a highly malignant primary nervous system tumor. Temozolomide（TMZ） is a commonly used chemotherapy drug, but drug resistance is increasing. Therefore, finding effective biomarkers can help us to better stratify and individualize treatment. Sirt7 is the latest member of sirtuins, which mainly plays the role of NAD+-dependent histone deacetylase. In recent years, Sirt7 has been report...

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Literature Corpus work: a919019a-0102-5206-9bc9-7c58062bf9bd
DOI: 10.21203/rs.3.rs-3977967/v1

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