Article
Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.
Cell reports - 13 Jul 2021
Singh Chingakham Ranjit, Glineburg M Rebecca, Moore Chelsea, Tani Naoki, Jaiswal Rahul, Zou Ye, Aube Eric, Gillaspie Sarah, Thornton Mackenzie, Cecil Ariana, Hilgers Madelyn, Takasu Azuma, Asano Izumi, Asano Masayo, Escalante Carlos R, Nakamura Akira, Todd Peter K, Asano Katsura
Abstract excerpt
eIF5-mimic protein (5MP) is a translational regulatory protein that binds the small ribosomal subunit and modulates its activity. 5MP is proposed to reprogram non-AUG translation rates for oncogenes in cancer, but its role in controlling non-AUG initiated synthesis of deleterious repeat-peptide products, such as FMRpolyG observed in fragile-X-associated tremor ataxia syndrome (FXTAS), is unknown. Here, we show...
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