Article

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

2021-01-08

Abstract excerpt

<h4>ABSTRACT</h4> Artemis (DCLRE1C) is an endonuclease that plays a key role in development of B- and T-lymphocytes and in DNA double-strand break repair by non-homologous end-joining (NHEJ). Artemis is phosphorylated by DNA-PKcs and acts to open DNA hairpin intermediates generated during V(D)J and class-switch recombination. Consistently, Artemis deficiency leads to radiosensitive congenital severe immune defici...

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Literature Corpus work: a86ade3a-6891-5c1e-ae89-b90d9287c09d
DOI: 10.1101/2021.01.08.423993

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