Article
The V(D)J recombination/DNA repair factor artemis belongs to the metallo-beta-lactamase family and constitutes a critical developmental checkpoint of the lymphoid system.
Annals of the New York Academy of Sciences - 1 Apr 2003
Moshous Despina, Callebaut Isabelle, de Chasseval Régina, Poinsignon Catherine, Villey Isabelle, Fischer Alain, de Villartay Jean-Pierre
Abstract excerpt
V(D)J recombination constitutes a critical checkpoint in the development of the immune system as shown in several animal models as well as severe combined immune deficiency (SCID) condition in humans. We recently cloned the Artemis gene, whose mutations are responsible for RS-SCID, a condition characterized by an absence of both B and T lymphocytes and associated with increased sensitivity to ionizing radiations....
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