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Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

12 Aug 2021

Abstract excerpt

Artemis (SNM1C/DCLRE1C) is an endonuclease that plays a key role in development of B- and T-lymphocytes and in dsDNA break repair by non-homologous end-joining (NHEJ). Artemis is phosphorylated by DNA-PKcs and acts to open DNA hairpin intermediates generated during V(D)J and class-switch recombination. Artemis deficiency leads to congenital radiosensitive severe acquired immune deficiency (RS-SCID). Artemis...

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PMID: 34387696
DOI: 10.1093/nar/gkab693

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Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibitionPMID 34387696Read ↗

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibitionSemantic proximity Read ↗

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