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Article

Physical ARTEMIS:DNA-PKcs interaction is necessary for V(D)J recombination

25 Jan 2022

Abstract excerpt

The nuclease ARTEMIS and the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) are involved in the repair of physiological and pathogenic DNA double strand breaks. Both proteins are indispensable for the hairpin-opening activity in V(D)J recombination and therefore essential for the adaptive immune response. ARTEMIS and DNA-PKcs interact, however experimental evidence for in vivo significance is missing....

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PMID: 35150269
DOI: 10.1093/nar/gkac071

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