Article

Neutralizing Antibodies with Neurotropic Factor Treatment Maintain Neurodevelopmental Gene Expression Upon Exposure to Human Cytomegalovirus

2023-03-02

Abstract excerpt

<h4>ABSTRACT</h4> Human cytomegalovirus (HCMV) is a beta herpesvirus that causes severe congenital birth defects including microcephaly, vision loss, and hearing loss. Infection of cerebral organoids with HCMV causes significant downregulation of genes involved in critical neurodevelopmental pathways. The precise features of the infection causing this dysregulation remain unknown. Entry of HCMV into human cells i...

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Literature Corpus work: a826eb03-ae31-5766-a603-f902e87b1545
DOI: 10.1101/2023.03.02.530870

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