Article

Antiviral efficacy versus host recovery: contrasting transcriptional footprints of four antivirals in human cytomegalovirus-infected brain organoids

2026-05-04

Abstract excerpt

Infection with human cytomegalovirus (HCMV) is common and usually asymptomatic in healthy individuals, but can cause severe neurological injury, particularly following congenital transmission. For symptomatic congenital infection, standard antiviral treatment is ganciclovir, with maribavir and letermovir as alternative direct-acting agents. However, their relative efficacy in clearing HCMV and restoring host trans...

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Literature Corpus work: bd8c6789-dd75-5b86-a159-bbda97a92cf6
DOI: 10.64898/2026.05.01.722178

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