Article

Polygenic associations with clinical and neuropathological trait heterogeneity across TDP-43 proteinopathies

2023-10-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> TDP-43 proteinopathies, including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with TDP-43 (FTLD-TDP), and limbic-predominant age-related TDP-43 encephalopathy, encompass a spectrum of clinical and neuropathological traits. Despite mounting evidence for shared genetic risk across TDP-43 proteinopathies, the modifiers of individual-level traits are un...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a7f4b2a0-c7dc-52bc-a260-26a01543a409
DOI: 10.1101/2023.10.05.23296613

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic associations with clinical and neuropathological trait heterogeneity across TDP-43 proteinopathiesDOI 10.1101/2023.10.05.23296613Read

Genetic risk factor clustering within and across neurodegenerative diseasesSemantic proximity Read

Pathway-specific polygenic risk scores correlate with clinical status and Alzheimer’s-related biomarkersSemantic proximity Read

Genetic risk factor clustering within and across neurodegenerative diseasesSemantic proximity Read

Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer's Disease-Related Biomarkers.Semantic proximity Read

Genetic architecture of FTLD-TDP pathological subtypes.Semantic proximity Read

Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer’s disease and related dementias in a multi-site autopsy cohortSemantic proximity Read

Large-scale pathway-specific polygenic risk, transcriptomic community networks and functional inferences in Parkinson diseaseSemantic proximity Read

Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease.Semantic proximity Read

Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.Semantic proximity Read

Polygenic risk and pleiotropy in neurodegenerative diseases.Semantic proximity Read

Contribution of rare variant associations to neurodegenerative disease presentationSemantic proximity Read

The genetics of TDP43-Type-C neurodegeneration: a whole genome sequencing studySemantic proximity Read