Genetic architecture of FTLD-TDP pathological subtypes.

Abstract excerpt

Until recently, few genetic risk factors had been identified for the distinct pathological subtypes of frontotemporal lobar degeneration (FTLD) with TDP-43 aggregation (FTLD-TDP). In a recent study, Pottier and colleagues addressed this gap by identifying common and rare genetic variants associated with FTLD-TDP subtypes, providing novel insights into the underlying mechanisms and heterogeneity of FTLD-TDP.

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