An appendiceal cancer organoid biobank identifies phenotypic evolution and druggable dependencies of peritoneal carcinomatosis.

doi:10.1016/j.devcel.2026.04.014

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An appendiceal cancer organoid biobank identifies phenotypic evolution and druggable dependencies of peritoneal carcinomatosis.

Developmental cell - 10 Jun 2026

Mahmoud Ahmed, Sukhwa Christine, Giarrizzo Michael, Choi Philip H, Pintar Jura, Walch Henry, Zhao Nan, Bermeo Jonathan, Chung Sebastian, Raghavan Manisha, Bapat Samhita, Jiang Qingwen, Meredith Julia, Firat Canan, Cercek Andrea, Foote Michael B, Schultz Nikolaus, Chatila Walid K, Nash Garrett M, Shia Jinru, Sanchez-Vega Francisco, Larson Steven, Dar Arvin C, Rosen Neal, Karagkounis Georgios, Ganesh Karuna

Abstract excerpt

Peritoneal carcinomatosis (PC) is a common yet deadly manifestation of gastrointestinal cancers, with few effective treatments. To identify targetable determinants of peritoneal metastasis, we focused on appendiceal adenocarcinoma (AC), which metastasizes almost exclusively to the peritoneum. No stable preclinical models of AC exist, limiting drug discovery and representing an unmet clinical need. We establish a...

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PMID: 42190666
DOI: 10.1016/j.devcel.2026.04.014
PMCID: PMC13231493

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