Article

Evolutionary potential of the monkeypox genome arising from interactions with human APOBEC3 enzymes

2023-06-28

Abstract excerpt

APOBEC3, an enzyme subfamily that plays a role in virus restriction by generating mutations at particular DNA motifs or mutational “hotspots,” can drive viral mutagenesis with host-specific preferential hotspot mutations contributing to pathogen variation. While previous analysis of viral genomes from the 2022 Mpox (formerly Monkeypox) disease outbreak has shown a high frequency of C>T mutations at T C motifs, su...

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Literature Corpus work: a7a905f5-acd5-55df-ae2d-ead6c68eb3e6
DOI: 10.1101/2023.06.27.546779

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