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Article

MPXV RNA-seq data provide evidence for protection of viral transcripts from APOBEC3 editing.

Journal of virology - 17 Feb 2026

Lyskova Alisa O, Abasov Ruslan Kh, Pavlova Anna, Matveev Evgenii V, Madorskaya Alexandra V, Kazanov Fedor M, Garshina Daria V, Smolnikova Anna E, Ponomarev Gennady V, Sharova Elena I, Ivankov Dmitry N, Adebali Ogun, Gelfand Mikhail S, Kazanov Marat D

Abstract excerpt

The 2022 outbreak of monkeypox virus (MPXV), a double-stranded DNA virus, is remarkable for an unusually high number of single-nucleotide substitutions compared to earlier strains, with a strong bias toward C→T and G→A transitions consistent with the APOBEC3 cytidine deaminase activity. While APOBEC3-induced mutagenesis is well documented at the DNA level, its potential impact on MPXV RNA transcripts remains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41589909
DOI: 10.1128/jvi.02082-25
PMCID: PMC12911903

Genes

APOBEC3A
APOBEC3B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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