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Article

Mpox Evolution: Has the Current Outbreak Revealed a Pox on "U"?

The Journal of infectious diseases - 28 Mar 2023

Kohli Rahul M, Isaacs Stuart N

Abstract excerpt

The recent mpox (monkeypox) outbreak has prompted genomic studies to track global spread of the disease. These studies have also revealed unexpected patterns of mutations that implicate the action of the immune defense APOBEC3 family of enzymes, which catalyze conversion of cytosine (C) to uracil (U) in DNA, in viral evolution. As poxviruses have conventionally been regarded as slow-evolving viruses, the rapid...

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PMID: 36481811
DOI: 10.1093/infdis/jiac471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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