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Article

An APOBEC3 Mutational Signature in the Genomes of Human-Infecting Orthopoxviruses.

mSphere - 20 Apr 2023

Forni Diego, Cagliani Rachele, Pozzoli Uberto, Sironi Manuela

Abstract excerpt

The ongoing worldwide monkeypox outbreak is caused by viral lineages (globally referred to as hMPXV1) that are related to but distinct from clade IIb MPXV viruses transmitted within Nigeria. Analysis of the genetic differences has indicated that APOBEC-mediated editing might be responsible for the unexpectedly high number of mutations observed in hMPXV1 genomes. Here, using 1,624 publicly available hMPXV1...

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Identifiers

PMID: 36920219
DOI: 10.1128/msphere.00062-23
PMCID: PMC10117092

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