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Selective events at individual sites underlie the evolution of monkeypox virus clades

1 Jan 2023

Abstract excerpt

In endemic regions (West Africa and the Congo Basin), the genetic diversity of monkeypox virus (MPXV) is geographically structured into two major clades (Clades I and II) that differ in virulence and host associations. Clade IIb is closely related to the B.1 lineage, which is dominating a worldwide outbreak initiated in 2022. Lineage B.1 has however accumulated mutations of unknown significance that most likely...

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PMID: 37305708
DOI: 10.1093/ve/vead031

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