Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of the Plasma and Tissue Kallikreins, and Their Alternative Splicing Isoforms

10 Jul 2013

Abstract excerpt

Kallikreins are secreted serine proteases with important roles in human physiology. Human plasma kallikrein, encoded by the KLKB1 gene on locus 4q34-35, functions in the blood coagulation pathway, and in regulating blood pressure. The human tissue kallikrein and kallikrein-related peptidases (KLKs) have diverse expression patterns and physiological roles, including cancer-related processes such as cell growth...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation and Thrombosis Mechanisms
Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
Share to Protease and Inhibitor Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23874499
DOI: 10.1371/journal.pone.0068074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of the Plasma and Tissue Kallikreins, and Their Alternative Splicing IsoformsPMID 23874499Read ↗

Evolutionary History of Tissue KallikreinsSemantic proximity Read ↗

The Expanded Human Kallikrein (KLK) Gene Family: Genomic Organisation, Tissue-Specific Expression and Potential FunctionsSemantic proximity Read ↗

The kallikrein world: an update on the human tissue kallikreinsSemantic proximity Read ↗

Human Tissue Kallikreins: Physiologic Roles and Applications in CancerSemantic proximity Read ↗

The Tissue Kallikrein Family of Serine Proteases: Functional Roles in Human Disease and Potential as Clinical BiomarkersSemantic proximity Read ↗

New insights into the functional mechanisms and clinical applications of the kallikrein‐related peptidase familySemantic proximity Read ↗

New Nomenclature for the Human Tissue Kallikrein Gene FamilySemantic proximity Read ↗

Evolution of kallikrein-related peptidases in mammals and identification of a genetic locus encoding potential regulatory inhibitorsSemantic proximity Read ↗

The physiology and pathobiology of human kallikrein-related peptidase 6 (KLK6).Semantic proximity Read ↗

An overview of the kallikrein gene families in humans and other species: emerging candidate tumour markersSemantic proximity Read ↗

The New Human Tissue Kallikrein Gene Family: Structure, Function, and Association to Disease*Semantic proximity Read ↗

Kallikrein-related peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers: do they have a function?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.