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Article

Modeling chemotherapeutic neurotoxicity with human induced pluripotent stem cell-derived neuronal cells.

PloS one - 1 Jan 2015

Wheeler Heather E, Wing Claudia, Delaney Shannon M, Komatsu Masaaki, Dolan M Eileen

Abstract excerpt

There are no effective agents to prevent or treat chemotherapy-induced peripheral neuropathy (CIPN), the most common non-hematologic toxicity of chemotherapy. Therefore, we sought to evaluate the utility of human neuron-like cells derived from induced pluripotent stem cells (iPSCs) as a means to study CIPN. We used high content imaging measurements of neurite outgrowth phenotypes to compare the changes that occur...

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Identifiers

PMID: 25689802
DOI: 10.1371/journal.pone.0118020
PMCID: PMC4331516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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