Article

Blockade of rheumatoid arthritis synovial fluid-induced sensory neuron activation by JAK inhibitors

2024-08-19

Abstract excerpt

<h4>Objective</h4> Clinical studies suggest that compared to anti-TNF treatment, JAK inhibitors (JAKi) are superior in reducing pain in rheumatoid arthritis (RA). The underlying mechanisms for this observation are still unknown. Sensory neurons transmit noxious signals from inflamed joints to the central nervous system, where a pain percept is generated. We investigated whether JAKi exert direct effects on sensor...

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Literature Corpus work: a765458d-ed43-5d45-8615-f8222d11d5d0
DOI: 10.1101/2024.08.19.608613

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