Article
Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2.
Nature - 4 Feb 2016
Liu Zhen, Li Xiao, Zhang Jun-Tao, Cai Yi-Jun, Cheng Tian-Lin, Cheng Cheng, Wang Yan, Zhang Chen-Chen, Nie Yan-Hong, Chen Zhi-Fang, Bian Wen-Jie, Zhang Ling, Xiao Jianqiu, Lu Bin, Zhang Yue-Fang, Zhang Xiao-Di, Sang Xiao, Wu Jia-Jia, Xu Xiu, Xiong Zhi-Qi, Zhang Feng, Yu Xiang, Gong Neng, Zhou Wen-Hao, Sun Qiang, Qiu Zilong
Abstract excerpt
Methyl-CpG binding protein 2 (MeCP2) has crucial roles in transcriptional regulation and microRNA processing. Mutations in the MECP2 gene are found in 90% of patients with Rett syndrome, a severe developmental disorder with autistic phenotypes. Duplications of MECP2-containing genomic segments cause the MECP2 duplication syndrome, which shares core symptoms with autism spectrum disorders. Although Mecp2-null mice...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.