Article

Advanced Glycation End-Products Suppress Mitochondrial Function and Proliferative Capacity of Achilles Tendon-Derived Fibroblasts

2019-07-18

Abstract excerpt

Debilitating cases of tendon pain and degeneration affect the majority of diabetic individuals. The high rate of tendon degeneration persists even when glucose levels are well controlled, suggesting that other mechanisms may drive tendon degeneration in diabetic patients. The purpose of this study was to investigate the impact of advanced glycation end-products on tendon fibroblasts to further our mechanistic unde...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a7331479-7ecb-5c1f-b1af-9c0bfc48d93e
DOI: 10.1101/706754

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Advanced Glycation End-Products Suppress Mitochondrial Function and Proliferative Capacity of Achilles Tendon-Derived FibroblastsDOI 10.1101/706754Read

Coordination of Glucose and Glutamine Metabolism in Tendon is Lost in AgingSemantic proximity Read

AMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcificationSemantic proximity Read

Palmitic acid reduces viability and increases production of reactive oxygen species and respiration in rat tendon-derived cellsSemantic proximity Read

Impaired function of tendon-derived stem cells in experimental diabetes mellitus rat tendons: implications for cellular mechanism of diabetic tendon disorderSemantic proximity Read

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviate Histological Damage and Modulate ADAM12 Gene Expression in the Type 2 Diabetic Rat Model of Achilles TendinopathySemantic proximity Read

An amino acid mixture, enriched with Krebs cycle intermediates, enhances extracellular matrix gene expression in cultured human fibroblastsSemantic proximity Read

Age-associated changes in the response of tendon explants to stress deprivation is sex-dependentSemantic proximity Read

Hyperglycemia Induces Bioenergetic Changes in Adipose-Derived Stromal Cells While Their Pericytic Function Is Retained.Semantic proximity Read

Tendon response to matrix unloading is determined by the patho-physiological nicheSemantic proximity Read

Elevated oxidative phosphorylation is critical for immune cell activation by polyethylene wear particlesSemantic proximity Read

Pathologic changes of Achilles tendon in leptin-deficient mice.Semantic proximity Read

Research progress in detection methods of biomechanics and metabolic changes of human tendonsSemantic proximity Read