Article

Tendon response to matrix unloading is determined by the patho-physiological niche

2019-04-26

Abstract excerpt

Aberrant matrix turnover with elevated matrix proteolysis is a hallmark of tendon pathology. While tendon disease mechanisms remain obscure, mechanical cues are central regulators. Unloading of tendon explants in standard culture conditions provokes rapid cell-mediated tissue breakdown. Here we show that biological response to tissue unloading depends on the mimicked physiological context. Our experiments reveal t...

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Literature Corpus work: ad47fedd-2543-57ee-9713-0c8d0464a693
DOI: 10.1101/620534

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