Article

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviate Histological Damage and Modulate ADAM12 Gene Expression in the Type 2 Diabetic Rat Model of Achilles Tendinopathy

2025-02-06

Abstract excerpt

<title>Abstract</title> <p>Diabetic Achilles tendinopathy (AT) is a degenerative disease resulting from changes in tendon tissue homeostasis caused by type 2 diabetes mellitus. The cure of diabetic AT is difficult to achieve due to the limited regeneration capacity of the tendon. Therefore, a new approach to effectively improve AT healing is needed for further investigation. Previous research has investigated the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d54e6253-c5da-509b-a76f-aaffee12683e
DOI: 10.21203/rs.3.rs-5955380/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviate Histological Damage and Modulate ADAM12 Gene Expression in the Type 2 Diabetic Rat Model of Achilles TendinopathyDOI 10.21203/rs.3.rs-5955380/v1Read

Impaired function of tendon-derived stem cells in experimental diabetes mellitus rat tendons: implications for cellular mechanism of diabetic tendon disorderSemantic proximity Read

Platelet-rich plasma-derived exosomes have the novel ability to alleviate insertional Achilles tendinopathy by promoting tenogenesis in tendon stem/progenitor cellsSemantic proximity Read

Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathySemantic proximity Read

iPSC-derived exosomes promote diabetic wound healing by attenuating inflammatory responsesSemantic proximity Read

Extracellular Vesicles from Inflammation-Primed Adipose-Derived Stem Cells Enhance Achilles Tendon Repair by Reducing Inflammation and Promoting Intrinsic HealingSemantic proximity Read

A “cell-free treatment” for tendon injuries: adipose stem cell-derived exosomesSemantic proximity Read

Therapeutic strategies for intervertebral disc degeneration: Extracellular vesicles and microRNAs derived from mesenchymal stem cellsSemantic proximity Read

Enhancing Tendon Regeneration: Investigating the Impact of Topography on the Secretome of Adipose-Derived Stem CellsSemantic proximity Read

Exosome-based strategy for degenerative disease in orthopedics: Recent progress and perspectivesSemantic proximity Read

Nanoscale Treatment of Intervertebral Disc Degeneration: Mesenchymal Stem Cell Exosome TransplantationSemantic proximity Read

Adipose stem cell-derived exosomes exert a synergic anti-inflammatory effect with glucocorticoids and override their detrimental effects on rotator cuff tendonsSemantic proximity Read

Elevated expression of MMP8 and MMP9 contributes to diabetic osteoarthritis progression in a rat modelSemantic proximity Read