Article

Clonotype pattern in T-cell lymphomas map the cell of origin to immature lymphoid precursors

2021-07-07

Abstract excerpt

<h4>Background</h4> Mature T-cell lymphomas (TCLs) are rare, clinically heterogeneous hematologic cancers of high medical need. TCLs have inferior prognosis compared with their B-cell counterparts, which is attributed to poor understanding of their pathogenesis. Based on phenotypic similarities between normal and neoplastic lymphocytes it has been assumed that TCLs develop in the periphery, directly from various s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a72e6ba7-1ff9-5f81-9a4c-94c06d3eb3b9
DOI: 10.1101/2021.07.05.21260052

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clonotype pattern in T-cell lymphomas map the cell of origin to immature lymphoid precursorsDOI 10.1101/2021.07.05.21260052Read

Clonotype pattern in T-cell lymphomas map the cell of origin to immature lymphoid precursorsSemantic proximity Read

Clonotypic Diversity of the T-cell Receptor Corroborates the Immature Precursor Origin of Cutaneous T-cell LymphomaSemantic proximity Read

Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphomaSemantic proximity Read

New insights into the biology of T-cell lymphomasSemantic proximity Read

Assessment of T-cell receptor repertoire and clonal expansion in peripheral T-cell lymphoma using RNA-seq data.Semantic proximity Read

Single-cell RNA sequencing comparison of CD4+, CD8+ and T-cell receptor γδ+ cutaneous T-cell lymphomas reveals subset-specific molecular phenotypes.Semantic proximity Read

Single-Cell Profiling Reveals Developmental Trajectories and identifies SYK and TIM3 as Targets in some T Cell LymphomasSemantic proximity Read

Advances in peripheral T cell lymphomas: pathogenesis, genetic landscapes and emerging therapeutic targetsSemantic proximity Read

T-cell receptor architecture and clonal tiding provide insight into the transformation trajectory of peripheral T-cell lymphomasSemantic proximity Read

A clonally expanded nodal T-cell population diagnosed as T-cell lymphoma after CAR-T therapySemantic proximity Read

Pathology of peripheral T-cell lymphomas: where do we stand?Semantic proximity Read

Indolent primary cutaneous B-cell lymphomas resemble persistent antigen reactions without signs of dedifferentiationSemantic proximity Read