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Article

Clonotype pattern in T-cell lymphomas map the cell of origin to immature lymphoid precursors

11 Jan 2022

Abstract excerpt

Mature T-cell lymphomas (TCLs) are rare, clinically heterogeneous hematologic cancers with high medical need. TCLs have an inferior prognosis which is attributed to poor understanding of their pathogenesis. On the basis of phenotypic similarities between normal and neoplastic lymphocytes, it has been assumed that TCLs develop in the periphery, directly from various subtypes of normal T cells. To address the...

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PMID: 35015812
DOI: 10.1182/bloodadvances.2021005884

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