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Article

A clonally expanded nodal T-cell population diagnosed as T-cell lymphoma after CAR-T therapy

12 Aug 2025

Abstract excerpt

Reports of secondary malignancies after chimeric antigen receptor (CAR)-T and possible CAR-T derived malignant transformation necessitate caution. Here we describe a patient with diffuse large B-cell lymphoma who developed new lymphadenopathy 2.5 years after CAR-T in the context of COVID-19 infection with histopathologic features consistent with T-cell lymphoma (TCL). Deep molecular interrogation with genomic...

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PMID: 40796743
DOI: 10.1038/s41467-025-62709-7

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