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Cross-disease genetic and epigenetic architecture of the <i>MOBP</i> locus shows convergence in ALS-PSP

2026-03-27

Abstract excerpt

Myelin oligodendrocyte basic protein ( MOBP ) is an abundant oligodendrocyte gene implicated in multiple neurodegenerative diseases. Genetic variation at the MOBP locus has been associated with risk for progressive supranuclear palsy (PSP), amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTD), corticobasal degeneration (CBD), Alzheimer’s disease (AD), Lewy body dementia (LBD), and Creutzf...

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Literature Corpus work
a729c5ec-59f1-5ab9-95d6-8c87b4174782
DOI
10.64898/2026.03.25.714147
Open publication

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