Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci.

doi:10.1007/s00401-016-1576-7

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Article

Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci.

Acta neuropathologica - 1 Aug 2016

Allen Mariet, Burgess Jeremy D, Ballard Travis, Serie Daniel, Wang Xue, Younkin Curtis S, Sun Zhifu, Kouri Naomi, Baheti Saurabh, Wang Chen, Carrasquillo Minerva M, Nguyen Thuy, Lincoln Sarah, Malphrus Kimberly, Murray Melissa, Golde Todd E, Price Nathan D, Younkin Steven G, Schellenberg Gerard D, Asmann Yan, Ordog Tamas, Crook Julia, Dickson Dennis, Ertekin-Taner Nilüfer

Abstract excerpt

To determine the effects of single nucleotide polymorphisms (SNPs) identified in a genome-wide association study of progressive supranuclear palsy (PSP), we tested their association with brain gene expression, CpG methylation and neuropathology. In 175 autopsied PSP subjects, we performed associations between seven PSP risk variants and temporal cortex levels of 20 genes in-cis, within ±100 kb. Methylation...

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PMID: 27115769
DOI: 10.1007/s00401-016-1576-7
PMCID: PMC4947429

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MOBP
MAPT

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