Article

Bioinformatics-Based Design Strategy and Development of an Antigen Test for SARS-CoV-2 Nucleocapsid Protein

2024-04-01

Abstract excerpt

The continuing mutability of the SARS-CoV-2 virus can result in failures of diagnostic assays. To address this, we describe a generalizable bioinformatics-to-biology pipeline developed for calibration and quality assurance of inactivated SARS-COV-2 variant panels provided to Radical Acceleration of Diagnostics programs (RADx)-radical program awardees. Heuristic genetic analysis based on variant-defining mutations...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a70fb07e-168b-51fa-804e-1c216de13e1e
DOI: 10.20944/preprints202404.0108.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bioinformatics-Based Design Strategy and Development of an Antigen Test for SARS-CoV-2 Nucleocapsid ProteinDOI 10.20944/preprints202404.0108.v1Read

Design and Development of an Antigen Test for SARS-CoV-2 Nucleocapsid Protein to Validate the Viral Quality Assurance Panels.Semantic proximity Read

Quantitative Mutation Analysis of Genes and Proteins of Major SARS-CoV-2 Variants of Concern and Interest.Semantic proximity Read

Algorithm for the Quantitation of Variants of Concern for Rationally Designed Vaccines Based on the Isolation of SARS-CoV-2 Hawaiʻi Lineage B.1.243Semantic proximity Read

Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen testsSemantic proximity Read

Predicting the mutational drivers of future SARS-CoV-2 variants of concern.Semantic proximity Read

SARS-CoV-2 Evolution and Its Implications for RT-PCR Diagnostic Performance.Semantic proximity Read

Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests.Semantic proximity Read

Predictive Modeling of Immune Escape and Antigenic Grouping of SARS-CoV-2 VariantsSemantic proximity Read

Digital PCR Discriminates between SARS-CoV-2 Omicron Variants and Immune Escape Mutations.Semantic proximity Read

Analytical comparison of nine SARS-CoV-2 antigen-detecting rapid diagnostic tests for emerging SARS-CoV-2 variantsSemantic proximity Read

Multiplex PCR Assays for Identifying All Major SARS-CoV-2 VariantsSemantic proximity Read

Highly Specific Monoclonal Antibodies Against SARS-CoV-2 Nucleocapsid Antigen for Accurate Diagnosis of COVID-19Semantic proximity Read