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Article

Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests.

Cell - 15 Sept 2022

Frank Filipp, Keen Meredith M, Rao Anuradha, Bassit Leda, Liu Xu, Bowers Heather B, Patel Anamika B, Cato Michael L, Sullivan Julie A, Greenleaf Morgan, Piantadosi Anne, Lam Wilbur A, Hudson William H, Ortlund Eric A

Abstract excerpt

The effects of mutations in continuously emerging variants of SARS-CoV-2 are a major concern for the performance of rapid antigen tests. To evaluate the impact of mutations on 17 antibodies used in 11 commercially available antigen tests with emergency use authorization, we measured antibody binding for all possible Nucleocapsid point mutations using a mammalian surface-display platform and deep mutational...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 36084631
DOI: 10.1016/j.cell.2022.08.010
PMCID: PMC9420710

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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