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Article

HuD, a Neuronal-specific RNA-binding Protein, Increases thein Vivo Stability of MYCN RNA

1 Jan 2002

Abstract excerpt

MYCN amplification and consequent deregulated expression plays a crucial role in determining the clinical behavior of neuroblastoma. Enhanced expression of MYCN confers growth potential to neuroblastoma cells, and a direct link between MYCN expression and the development of neuroblastoma has been demonstrated in transgenic mice studies. Although the molecular pathways underlying the regulation of MYCN have not...

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PMID: 11711535
DOI: 10.1074/jbc.m106966200

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HuD, a Neuronal-specific RNA-binding Protein, Increases thein Vivo Stability of MYCN RNAPMID 11711535Read ↗

HuD, a neuronal-specific RNA-binding protein, is a putative regulator of N-myc pre-mRNA processing/stability in malignant human neuroblastsSemantic proximity Read ↗

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Loss of one HuD allele on chromosome #1p selects for amplification of the N-myc proto-oncogene in human neuroblastoma cells.Semantic proximity Read ↗

NCYM, a Cis-Antisense Gene of MYCN, Encodes a De Novo Evolved Protein That Inhibits GSK3β Resulting in the Stabilization of MYCN in Human NeuroblastomasSemantic proximity Read ↗

Noncoding elements within <i>MYCN</i> mRNA are autonomous drivers of oncogenesis in neuroblastomaSemantic proximity Read ↗

Overlapping Activities of ELAV/Hu Family RNA Binding Proteins Specify the Extended Neuronal 3' UTR Landscape in Drosophila.Semantic proximity Read ↗

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Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27Kip1 levels and poor prognosis.Semantic proximity Read ↗

Effects of a Novel Long Noncoding RNA, lncUSMycN, on N-Myc Expression and Neuroblastoma ProgressionSemantic proximity Read ↗

miRNA Expression Profiling of the Murine TH-MYCN Neuroblastoma Model Reveals Similarities with Human Tumors and Identifies Novel Candidate MiRNAsSemantic proximity Read ↗

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