Article

Immunization by replication-competent controlled herpesvirus vectors

2018-04-11

Abstract excerpt

<h4>ABSTRACT</h4> Replication-competent controlled virus vectors were derived from virulent HSV-1 wildtype strain 17 syn + by placing one or two replication-essential genes under the stringent control of a gene switch that is co-activated by heat and an antiprogestin. Upon activation of the gene switch, the vectors replicate in infected cells with an efficacy that approaches that of the wildtype virus from which...

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Literature Corpus work: a6e5aa51-0267-52f5-b046-75c13cea9ca9
DOI: 10.1101/299230

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